We review the standard model for de novo computational design of enzymes, which
primarily focuses on the development of an active-site geometry, composed of protein …

Two-dimensional infrared spectroscopy of amide I vibrations is increasingly being used to
study the structure and dynamics of proteins and peptides. Amide I, a primarily carbonyl …

Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins
that respond to peptide hormones, has been restricted to the amino-terminal extracellular …

It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly
growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) …

Spinach is an in vitro–selected RNA aptamer that binds a GFP-like ligand and activates its
green fluorescence. Spinach is thus an RNA analog of GFP and has potentially widespread …

The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple
photosynthetic bacteria form a supramolecular complex (LH1–RC) to use sunlight energy in …

Refinement of macromolecular structures against low-resolution crystallographic data is
limited by the ability of current methods to converge on a structure with realistic geometry …

Human Vγ9Vδ2 T cells are well known for their rapid and potent response to infection and
tumorigenesis when in the presence of endogenous or exogenous phosphoisoprenoids …

Glutaminase (GLS1/2) catalyzes the conversion of l-glutamine to l-glutamate and ammonia.
The level of a splice variant of GLS1 (GAC) is elevated in certain cancers, and GAC is …

The rise of the computer as a powerful tool for model building and refinement has
revolutionized the field of structure determination for large biomolecular systems. Despite …