Device-based solutions to improve cardiac physiology and hemodynamics in heart failure with preserved ejection fraction

L Rosalia, C Ozturk, S Shoar, Y Fan, G Malone… - Basic to Translational …, 2021 - jacc.org
Characterized by a rapidly increasing prevalence, elevated mortality and rehospitalization
rates, and inadequacy of pharmaceutical therapies, heart failure with preserved ejection …

Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction

AM Troy, D Normukhamedova… - American Journal …, 2024 - journals.physiology.org
Heart failure with preserved ejection fraction (HFpEF) afflicts over half of all patients with
heart failure and is a debilitating and fatal syndrome affecting postmenopausal women more …

Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase PDE9

RP Ceddia, D Liu, F Shi, MK Crowder, S Mishra… - Diabetes, 2021 - Am Diabetes Assoc
Cyclic nucleotides cAMP and cGMP are important second messengers for the regulation of
adaptive thermogenesis. Their levels are controlled not only by their synthesis, but also their …