Therapeutic choice in older patients with acute myeloid leukemia: a matter of fitness

R Palmieri, G Paterno, E De Bellis, L Mercante… - Cancers, 2020 - mdpi.com
Acute myeloid leukemia (AML), with an incidence increasing with age, is the most common
acute leukemia in adults. Concurrent comorbidities, mild to severe organ dysfunctions, and …

The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global …

M Yi, A Li, L Zhou, Q Chu, Y Song, K Wu - Journal of hematology & …, 2020 - Springer
Background Acute myeloid leukemia (AML) is a common leukemia subtype and has a poor
prognosis. The risk of AML is highly related to age. In the context of population aging, a …

Current therapeutic results and treatment options for older patients with relapsed acute myeloid leukemia

F Ferrara, F Lessi, O Vitagliano, E Birkenghi, G Rossi - Cancers, 2019 - mdpi.com
Considerable progress has been made in the treatment of acute myeloid leukemia (AML).
However, current therapeutic results are still unsatisfactory in untreated high-risk patients …

The global burden of leukemia and its attributable factors in 204 countries and territories: findings from the global burden of disease 2019 study and projections to …

M Du, W Chen, K Liu, L Wang, Y Hu, Y Mao… - Journal of …, 2022 - Wiley Online Library
Background. Leukemia is a common malignancy that has four main subtypes and is a threat
to human health. Understanding the epidemiological status of leukemia and its four main …

Venetoclax with decitabine vs intensive chemotherapy in acute myeloid leukemia: a propensity score matched analysis stratified by risk of treatment‐related mortality

A Maiti, W Qiao, K Sasaki, F Ravandi… - American journal of …, 2021 - Wiley Online Library
Hypomethylating agents (HMA) with venetoclax is a new standard for older/unfit patients
with acute myeloid leukemia (AML). However, it is unknown how HMA with venetoclax …

A high hematopoietic cell transplantation comorbidity Index (HCT-CI) does not impair outcomes after non-myeloablative allogeneic stem cell transplantation in acute …

D Backhaus, D Brauer, R Pointner, L Bischof… - Bone Marrow …, 2023 - nature.com
For most acute myeloid leukemia (AML) patients an allogeneic hematopoietic stem cell
transplantation (HSCT) offers the highest chance of cure. The introduction of less toxic non …

Venetoclax combinations induce high response rates in newly diagnosed acute myeloid leukemia patients ineligible for intensive chemotherapy in routine practice

A Apel, Y Moshe, Y Ofran, A Gural… - American Journal of …, 2021 - Wiley Online Library
Combinations of the BCL‐2 inhibitor, venetoclax, with either hypomethylating agents (HMA)
or low dose cytarabine (LDAC), have shown promising results in clinical trials of AML …

[HTML][HTML] Recent advances in allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

MCB Bittencourt, SO Ciurea - Biology of Blood and Marrow Transplantation, 2020 - Elsevier
Allogeneic hematopoietic stem cell transplantation remains an important treatment modality
for patients with acute myeloid leukemia (AML). Recent advances have extended donor …

Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: a systematic review

X Zeng, L Zhang, Y Zhang, S Jia, T Lin, X Zhao… - Frontiers in …, 2023 - frontiersin.org
Background The correlation between sarcopenia and hematological malignancy prognosis
is still controversial. Design: A systematic review and meta-analysis. Objectives: To explore …

Venetoclax and hypomethylating agents in octogenarians and nonagenarians with acute myeloid leukemia

E Madarang, J Lykon, W Zhao, MA Sekeres… - Blood …, 2024 - ashpublications.org
Venetoclax (VEN) plus a hypomethylating agent (HMA) regimen is the standard of care for
older adults with acute myeloid leukemia (AML); however, it is associated with significant …