Doxorubicin is one of the most important anti-cancer chemotherapeutic drugs, being widely
used for the treatment of solid tumors and acute leukemias. The action of doxorubicin and …

This review provides an update on the mutagenicity of intercalating chemicals, as carried out
over the last 17 years. The most extensively studied DNA intercalating agents are acridine …

Doxorubicin is an anthracycline DNA intercalator that is among the most commonly used
anticancer drugs [1]. Doxorubicin causes DNA double-strand breaks in rapidly dividing cells …

The single-molecule tracking of transmembrane receptors in living cells has provided
significant insights into signaling mechanisms, such as mobility and clustering upon their …

Acute myeloid leukemia (AML) is a hematological malignancy commonly found in adult
patients. Low overall survival and resistance to therapy are the main issues in AML. The first …

For the development of novel anticancer agents, we designed and synthesized a total of 37
perimidine o-quinone derivatives containing the o-quinone group at the A or B ring and …

To overcome the problems associated with polypharmacy, which include medication non
compliance, adverse drug reactions, drug–drug interactions and increased pill-burden …

Gene expression profiling technology is expected to advance our understanding of
genotoxic mechanisms involving direct or indirect interaction with DNA. We exposed human …

Zinc is one of the most essential trace elements in human organism. Low blood level of zinc
is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is …

Among the great number of studies on the chemical and biological features of propolis from
Brazil, none have been found on the evaluation of the biological properties of propolis from …