Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The promises and perils of psychedelic pharmacology for psychiatry

TD McClure-Begley, BL Roth - Nature Reviews Drug Discovery, 2022 - nature.com
Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

ACT Ng, V Delgado, BA Borlaug, JJ Bax - Nature Reviews Cardiology, 2021 - nature.com
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

[HTML][HTML] Lipase inhibitors for obesity: A review

TT Liu, XT Liu, QX Chen, Y Shi - Biomedicine & Pharmacotherapy, 2020 - Elsevier
With the rapid increase in the population of obese individuals, obesity has become a global
problem. Many kinds of chronic metabolic diseases easily caused by obesity have received …

International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

NM Barnes, GP Ahern, C Becamel, J Bockaert… - Pharmacological …, 2021 - ASPET
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

L Lagae, J Sullivan, K Knupp, L Laux, T Polster… - The Lancet, 2019 - thelancet.com
Background Dravet syndrome is a rare, treatment-resistant developmental epileptic
encephalopathy characterised by multiple types of frequent, disabling seizures …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - ASPET
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

AGA clinical practice guideline on pharmacological interventions for adults with obesity

E Grunvald, R Shah, R Hernaez, AK Chandar… - Gastroenterology, 2022 - Elsevier
Background & Aims Pharmacological management of obesity improves outcomes and
decreases the risk of obesity-related complications. This American Gastroenterological …

Current pharmacotherapy for obesity

G Srivastava, CM Apovian - Nature Reviews Endocrinology, 2018 - nature.com
More than one-third of adults in the USA have obesity, which causes, exacerbates or
adversely impacts numerous medical comorbidities, including diabetes mellitus and …