Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …

Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …

The Genome 10K Project was established in 2009 by a consortium of biologists and
genome scientists determined to facilitate the sequencing and analysis of the complete …

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are
widely used in mammalian cell line engineering research. To elucidate metabolic …

Production of glycoprotein therapeutics in Chinese hamster ovary (CHO) cells is limited by
the cells' generic capacity for N-glycosylation, and production of glycoproteins with desirable …

Advances in next-generation sequencing (NGS) technologies have rapidly improved
sequencing fidelity and substantially decreased sequencing error rates. However, given that …

Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for
production of therapeutic proteins. However, development of recombinant CHO cell lines …

This review describes key milestones related to the production of biopharmaceuticals—
therapies manufactured using recombinant DNA technology. The market for …

Landfill leachate is a complex mixture characterized by high toxicity and able to contaminate
soils and waters surrounding the dumpsite, especially in developing countries where …

Engineering mammalian cell lines that stably express many transgenes requires the precise
insertion of large amounts of heterologous DNA into well-characterized genomic loci, but …