CD44 has been the subject of extensive research for more than 3 decades because of its
role in breast cancer, in addition to many physiological processes, but interestingly …

Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma.
The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are …

MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many
biological processes,. Although the oncogenic and tumour-suppressive functions of several …

Metastasis is the predominant cause of death from cancer yet we have few biomarkers to
predict patients at increased risk of metastasis and are unable to effectively treat …

Background The CD44 transmembrane glycoproteins play multifaceted roles in tumor
progression and metastasis. CD44 expression has also been associated with stem-like …

Triple‐negative breast cancer (TNBC) has a significant clinical relevance of being
associated with a shorter median time to relapse and death and does not respond to …

The cancer stem cell theory poses that cancers develop from a subset of malignant cells that
possess stem cell characteristics and has been proposed to account for the development of …

The hyaluronan receptor CD44 plays an important role in facilitating invasion and
metastasis of a variety of tumors, including breast carcinomas. CD44 functions as a bioactive …

Purpose: CD44 is a multifunctional cell surface receptor with many known splice variants,
some of which have been reported to play a role in tumor progression. The purpose of this …

The ability to prospectively isolate breast cancer cells that initiate tumors when transplanted
orthotopically into immunocompromised mice has led to an explosion of work characterizing …