Transcriptomic and metabolomic data integration

R Cavill, D Jennen, J Kleinjans… - Briefings in …, 2016 - academic.oup.com
Many studies now produce parallel data sets from different omics technologies; however, the
task of interpreting the acquired data in an integrated fashion is not trivial. This review covers …

The human early-life exposome (HELIX): project rationale and design

M Vrijheid, R Slama, O Robinson… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Developmental periods in early life may be particularly vulnerable to impacts of
environmental exposures. Human research on this topic has generally focused on single …

Deep learning accurately predicts estrogen receptor status in breast cancer metabolomics data

FM Alakwaa, K Chaudhary… - Journal of proteome …, 2018 - ACS Publications
Metabolomics holds the promise as a new technology to diagnose highly heterogeneous
diseases. Conventionally, metabolomics data analysis for diagnosis is done using various …

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

A Kamburov, R Cavill, TMD Ebbels, R Herwig… - …, 2011 - academic.oup.com
Pathway-level analysis is a powerful approach enabling interpretation of post-genomic data
at a higher level than that of individual biomolecules. Yet, it is currently hard to integrate …

Approaches to integrating metabolomics and multi-omics data: a primer

T Jendoubi - Metabolites, 2021 - mdpi.com
Metabolomics deals with multiple and complex chemical reactions within living organisms
and how these are influenced by external or internal perturbations. It lies at the heart of …

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

A Jaiswal, A Verma, R Dannenfelser, M Melssen… - Cancer Cell, 2022 - cell.com
There is a need for better classification and understanding of tumor-infiltrating lymphocytes
(TILs). Here, we applied advanced functional genomics to interrogate 9,000 human tumors …

Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology

R Kaddurah‐Daouk, RM Weinshilboum… - Clinical …, 2014 - Wiley Online Library
Metabolomics, the study of metabolism at an “omic” level, has the potential to transform our
understanding of mechanisms of drug action and the molecular basis for variation in drug …

[HTML][HTML] Metabolomics in toxicology and preclinical research

T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench… - Altex, 2013 - ncbi.nlm.nih.gov
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides
detailed information about the biochemical/physiological status of a biological system, and …

The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma

M Lewinska, A Santos-Laso, E Arretxe, C Alonso… - …, 2021 - thelancet.com
Background Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally.
Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular …

Leveraging multilayered “omics” data for atopic dermatitis: a road map to precision medicine

D Ghosh, JA Bernstein, GK Khurana Hershey… - Frontiers in …, 2018 - frontiersin.org
Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects~ 280
million people worldwide. About 85% of AD cases begin in childhood, a significant portion of …