Saccharomyces cerevisiae adapts to oxidative, osmotic stress and nutrient deprivation
through transcriptional changes, decreased proliferation, and entry into other developmental …

Inositol polyphosphates are a diverse and multifaceted class of intracellular messengers
omnipresent in eukaryotic cells. These water-soluble molecules regulate many aspects of …

The yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a
Nudix enzyme with pyrophosphatase activity on diphosphoinositides, dinucleotides, and …

Intracellular signaling is conserved in eukaryotes to allow for response to extracellular
signals and to regulate development and cellular functions. In fungi, inositol phosphate …

Cells convert complex metabolic information into stress-adapted autophagy responses.
Canonically, multilayered protein kinase networks converge on the conserved Atg1/ULK …

The ascomycete Botrytis cinerea is one of the most relevant plant pathogenic fungi, affecting
fruits, flowers, and greenhouse-grown crops. The infection strategy used by the fungus …

Abstract Background The Ceratocystis genus harbors a large number of phytopathogenic
fungi that cause xylem parenchyma degradation and vascular destruction on a broad range …

Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens,
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …

New antifungals with unique modes of action are urgently needed to treat the increasing
global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) …

Inositol polyphosphates (IPs) and inositol pyrophosphates (PP–IPs) regulate diverse cellular
processes in eukaryotic cells. IPs and PP–IPs are highly negatively charged and exert their …