Current and emerging therapies for corneal neovascularization

D Roshandel, M Eslani, A Baradaran-Rafii… - The ocular …, 2018 - Elsevier
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …

Mesenchymal stem cells improve healing of diabetic foot ulcer

Y Cao, X Gang, C Sun, G Wang - Journal of diabetes research, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no
ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has …

Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety

UV Jurkunas, J Yin, LK Johns, S Li, H Negre… - Science …, 2023 - science.org
To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous
limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic …

[HTML][HTML] Simple limbal epithelial transplantation: long-term clinical outcomes in 125 cases of unilateral chronic ocular surface burns

S Basu, SP Sureka, SS Shanbhag, AR Kethiri, V Singh… - Ophthalmology, 2016 - Elsevier
Purpose This study describes the long-term clinical outcomes of autologous simple limbal
epithelial transplantation (SLET), a relatively new technique of limbal stem cell …

Limbal stem cell deficiency: current treatment options and emerging therapies

M Haagdorens, SI Van Acker… - Stem cells …, 2016 - Wiley Online Library
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

Human limbal epithelial stem cell regulation, bioengineering and function

C Bonnet, S González, JAS Roberts… - Progress in retinal and …, 2021 - Elsevier
The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

Simple limbal epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact

SS Shanbhag, CN Patel, R Goyal… - Indian journal of …, 2019 - journals.lww.com
Simple limbal epithelial transplantation (SLET) is an innovative limbal stem cell
transplantation technique that has gained increasing popularity over the last few years …

The use of stem cells in burn wound healing: a review

F Ghieh, R Jurjus, A Ibrahim… - BioMed research …, 2015 - Wiley Online Library
Burn wound healing involves a series of complex processes which are subject to intensive
investigations to improve the outcomes, in particular, the healing time and the quality of the …

Limbal stem cell transplantation and complications

J Yin, U Jurkunas - Seminars in ophthalmology, 2018 - Taylor & Francis
Corneal epithelial stem cells are adult somatic stem cells located at the limbus and
represent the ultimate source of transparent corneal epithelium. When these limbal stem …

Limbal stem cell transplantation: current perspectives

MR Atallah, S Palioura, VL Perez… - Clinical …, 2016 - Taylor & Francis
Regeneration of the corneal surface after an epithelial insult involves division, migration,
and maturation of a specialized group of stem cells located in the limbus. Several insults …