Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate
all mature blood cells. HSC function is tightly controlled to maintain haematopoietic …

The bone marrow microenvironment (BMM) plays a critical role in hematopoietic stem cells
(HSCs) maintenance and regulation. There is increasing interest in the role of the BMM in …

The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet
a more systematic investigation into the microenvironment regulation of hematopoiesis in …

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) has limited
efficacy against leukemia stem cells (LSC) responsible for disease propagation, and most …

Liver fibrosis is caused by chronic liver injury. There are limited treatments for it, and the
pathogenesis is unclear. Therefore, there is an urgent need to explore the pathogenesis of …

OBJECTIVE: To investigate the role of the blastocyst in implantation failure. This study
examined trophectoderm (TE) gene expression relative to pregnancy outcome. DESIGN …

T cell-mediated immune responses to the grafted tissues are the major reason for failed
organ transplantation. The regulation of T cell responses is complex and involves major …

Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow
transplants, but finding immune-compatible donors limits treatment availability and efficacy …

The generation of hematopoietic stem cells (HSCs) during development is a complex
process linked to morphogenic signals. Understanding this process is important for …

In contrast to all other blood and immune cells, T lymphocytes do not develop in the bone
marrow (BM), but in the specialized microenvironment provided by the thymus. Similar to the …