The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …

A ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme in
polyunsaturated fatty acid (PUFA) metabolism. The role of ACSL4 in the lipopolysaccharide …

Necroptosis, a form of programmed cell death, is characterized by the loss of membrane
integrity and release of intracellular contents, the execution of which depends on the …

Background. Curcumin is a polyphenol plant‐derived compound with anti‐inflammatory,
antioxidant stress, and anticancer properties that make it have the potential to treat cancer …

Background Mitochondria have an essential role in regulating metabolism and integrate
environmental and physiological signals to affect processes such as cellular bioenergetics …

Abstract We examined YAP1/TAZ-TEAD signaling pathway activity at neuromuscular
junctions (NMJs) of skeletal muscle fibers in adult mice. Our investigations revealed that …

VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone
development and bone homeostasis remains unclear. In this study, we demonstrated that …