Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling
Q Yuan, D Verbueken, R Dinani, R Kim, E Schoger… - Stem Cell Reports, 2024 - cell.com
Embryonic signaling pathways exert stage-specific effects during cardiac development, yet
the precise signals for proliferation or maturation remain elusive. To uncover the cues for …
the precise signals for proliferation or maturation remain elusive. To uncover the cues for …
[HTML][HTML] Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Preclinical Cardiotoxicity Screening in Cardio-Oncology
Highlights• hiPSC-CM offer an alternative to in vivo models for predicting cardiotoxicity.•
hiPSC-CM monolayers detect pro-arrhythmic effects; inotropic detection is less established.• …
hiPSC-CM monolayers detect pro-arrhythmic effects; inotropic detection is less established.• …
[HTML][HTML] Enhancing Maturation and Translatability of Human Pluripotent Stem Cell-Derived Cardiomyocytes through a Novel Medium Containing Acetyl-CoA …
C Correia, J Christoffersson, S Tejedor, S El-Haou… - Cells, 2024 - mdpi.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) constitute an appealing
tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their …
tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their …