A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The published data of the last 15 years on the antiviral activity and the mechanism of action
of cage compounds are integrated and described systematically. The considerable interest …

Amantadine inhibits the M2 proton channel of influenza A virus, yet its clinical use has been
limited by the rapid emergence of amantadine-resistant virus strains. We have synthesized …

The amino-functionalization of a range of benzylic and some aliphatic saturated and
unsaturated hydrocarbons by reaction with imido-iodinanes (PhI NSO2Ar) is catalyzed by …

A heterocycle is an important structural scaffold of many organic compounds found in
pharmaceuticals, materials, agrochemicals, and biological processes. Azacycles are one of …

Adamantanamines 16, 18, 21, 24, 27, 28, 30, 32, 35, 36, 37, 40, 46 and 48 were synthesized
and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic …

The synthesis of several (3-noradamantyl) amines,[(3-noradamantyl) methyl] amines,(3, 7-
dimethyl-1-bisnoradamantyl) amines, and [(3, 7-dimethyl-1-bisnoradamantyl) methyl] …

We examined whether the incorporation of a second amino group into the 1-aminoethyl
pharmacophore of rimantadine 2 and into the piperidine pharmacophore of the heterocyclic …

The synthesis of several (2-oxaadamant-1-yl) amines is reported. They were evaluated as
NMDA receptor antagonists and several of them were more active than amantadine, but …

Обобщены и систематизированы литературные данные по антивирусной активности
и механизму действия каркасных соединений за последние 15 лет. Значительный …