[HTML][HTML] Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations
Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …
European descent, but it is essential that diverse populations become better represented …
[HTML][HTML] A one-penny imputed genome from next-generation reference panels
Genotype imputation is commonly performed in genome-wide association studies because it
greatly increases the number of markers that can be tested for association with a trait. In …
greatly increases the number of markers that can be tested for association with a trait. In …
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Metabolomics examines the small molecules involved in cellular metabolism. Approximately
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
Use of> 100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare …
MH Kowalski, H Qian, Z Hou, JD Rosen, AL Tapia… - PLoS …, 2019 - journals.plos.org
Most genome-wide association and fine-mapping studies to date have been conducted in
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …
Common genetic variation influencing human white matter microstructure
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-
risk subtype with an expression signature resembling that of Philadelphia chromosome …
risk subtype with an expression signature resembling that of Philadelphia chromosome …
Novel methods to optimize genotypic imputation for low‐coverage, next‐generation sequence data in crop plants
Next‐generation sequencing technology such as genotyping‐by‐sequencing (GBS) made
low‐cost, but often low‐coverage, whole‐genome sequencing widely available. Extensive …
low‐cost, but often low‐coverage, whole‐genome sequencing widely available. Extensive …
Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study
Objective To determine if circulating concentrations of vitamin D are causally associated with
risk of cancer. Design Mendelian randomisation study. Setting Large genetic epidemiology …
risk of cancer. Design Mendelian randomisation study. Setting Large genetic epidemiology …
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis
Genome-wide association studies (GWASs) have linked genes to various pathological traits.
However, the potential contribution of regulatory noncoding RNAs, such as microRNAs …
However, the potential contribution of regulatory noncoding RNAs, such as microRNAs …