Gout is a common type of inflammatory arthritis characterized by the presence of
monosodium urate crystals (MSU) in the joints. Macrophages are believed to be involved in …

The COVID-19 pandemic caused by SARS-CoV-2 has been identified as a culprit in the
development of a variety of disorders, including arthritis. Although the emergence of arthritis …

Excessive inflammatory reactions caused by uric acid deposition are the key factor leading
to gout. However, clinical medications cannot simultaneously remove uric acid and eliminate …

Introduction Untreated gout is characterised by monosodium urate (MSU) crystal
accumulation responsible for recurrent flares that are commonly separated by asymptomatic …

Abstract Peptidylarginine deiminase 4 (PAD4)-dependent neutrophil extracellular trap (NET)
formation is a new neutrophil death mechanism. Increased NET formation has been …

Background Activation of the NLRP3 inflammasome is critical in the inflammatory response
to gout. Potassium ion (K+) efflux mediated by the TWIK2 channel is an important upstream …

Background Macrophages, a key class of immune cells, have a dual role in inflammatory
responses, switching between anti-inflammatory M2 and pro-inflammatory M1 subtypes …

Abstract Ethnopharmacological relevance Modified Simiaowan (MSM) is a six-herb formula
that has been shown to be effective in gouty arthritis (GA) has been proven, but its regulatory …

Abstract Ethnopharmacological relevance Elsholtzia bodinieri Vaniot, perennial herbs, a
traditional Yunnan Chinese herbal medicine. Its whole herb can be used as commonly used …

Gout represents an autoinflammatory disorder instigated by monosodium urate crystals. Its
primary manifestation involves the recruitment of diverse immune cell populations, including …