Role of human milk bioactives on infants' gut and immune health

LE Carr, MD Virmani, F Rosa, D Munblit… - Frontiers in …, 2021 - frontiersin.org
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …

Effects of maternal and paternal exercise on offspring metabolism

J Kusuyama, AB Alves-Wagner, NS Makarewicz… - Nature …, 2020 - nature.com
Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …

High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis

X Liu, X Li, B Xia, X Jin, Q Zou, Z Zeng, W Zhao, S Yan… - Cell metabolism, 2021 - cell.com
Maternal obesity has been reported to be related to neurodevelopmental disorders in the
offspring. However, the underlying mechanisms and effective interventions remain unclear …

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

B Chen, YR Du, H Zhu, ML Sun, C Wang, Y Cheng… - Nature, 2022 - nature.com
Diabetes mellitus is prevalent among women of reproductive age, and many women are left
undiagnosed or untreated. Gestational diabetes has profound and enduring effects on the …

Human milk oligosaccharides: their effects on the host and their potential as therapeutic agents

A Rousseaux, C Brosseau, S Le Gall… - Frontiers in …, 2021 - frontiersin.org
Breastmilk is known to be very important for infants because it provides nutrients and
immunological compounds. Among these compounds, human milk oligosaccharides …

Regulation of maternal–fetal metabolic communication

CE Bowman, Z Arany, MJ Wolfgang - Cellular and molecular life sciences, 2021 - Springer
Pregnancy may be the most nutritionally sensitive stage in the life cycle, and improved
metabolic health during gestation and early postnatal life can reduce the risk of chronic …

Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose

Y Zhu, J Zhang, W Zhang, W Mu - Biotechnology Advances, 2023 - Elsevier
Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Combinatorial metabolic engineering of Escherichia coli for de novo production of 2′-fucosyllactose

L Lin, M Gong, Y Liu, J Li, X Lv, G Du, L Liu - Bioresource Technology, 2022 - Elsevier
Fucosyllactose (2′-FL) is a kind of fucosylated lactose of human milk oligosaccharides
(HMOs). In this work, Escherichia coli MG1655 was metabolically engineered to increase …

Biology of human milk oligosaccharides: From basic science to clinical evidence

N Sprenger, HLP Tytgat, A Binia… - Journal of Human …, 2022 - Wiley Online Library
Human milk oligosaccharides (HMOs) have been researched by scientists for over 100
years, driven by the substantial evidence for the nutritional and health benefits of mother's …

Linking human milk oligosaccharide metabolism and early life gut microbiota: Bifidobacteria and beyond

C Lordan, AK Roche, D Delsing, A Nauta… - Microbiology and …, 2024 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in
human breast milk. They represent an intricate mix of heterogeneous structures which reach …