Novel 1, 2, 4‐Triazoles as Antifungal Agents

Z Kazeminejad, M Marzi, A Shiroudi… - BioMed Research …, 2022 - Wiley Online Library
The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

A review on the antimicrobial assessment of triazole-azomethine functionalized frameworks incorporating transition metals

W Zafar, M Ashfaq, SH Sumrra - Journal of Molecular Structure, 2023 - Elsevier
Antimicrobial resistance is a growing threat to global public health that calls for innovative
strategies to develop new methods of action against resistance to emerging infectious …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Discovery of novel dual adenosine A1/A2A receptor antagonists using deep learning, pharmacophore modeling and molecular docking

M Wang, S Hou, Y Wei, D Li, J Lin - PLoS computational biology, 2021 - journals.plos.org
Adenosine receptors (ARs) have been demonstrated to be potential therapeutic targets
against Parkinson's disease (PD). In the present study, we describe a multistage virtual …

Novel triazoles with potent and broad-spectrum antifungal activity in vitro and in vivo

P Zhu, T Zhou, H Chen, X Chen, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
Triazoles have demonstrated significant efficacy in the treatment of fungal infections.
However, increasing drug resistance is a growing concern that negatively impacts their …

Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods

RB Vlocskó, G Xie, B Török - Molecules, 2023 - mdpi.com
Recent advances in the environmentally benign synthesis of aromatic N-heterocycles are
reviewed, focusing primarily on the application of catalytic methods and non-traditional …

Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents

O Moussaoui, R Bhadane, R Sghyar, J Ilaš… - …, 2022 - Wiley Online Library
Due to the ever‐increasing antimicrobial resistance there is an urgent need to continuously
design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities …

Synthetic and Medicinal Perspective of 1, 2, 4‐Triazole as Anticancer Agents

B Rathod, K Kumar - Chemistry & Biodiversity, 2022 - Wiley Online Library
Cancer is still one of the leading causes of death worldwide. Many researchers are working
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …

Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics

S Deshkar, P Yeole, J Mahore, A Shinde, P Giram - Gels, 2023 - mdpi.com
Worldwide, 40 to 50% of women suffer from reproductive tract infections. Most of these
infections are mixed infections, are recurrent and difficult to treat with antimicrobials or …

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1, 2, 4-triazole

Y Sameliuk, A Kaplaushenko… - … University Journal of …, 2022 - dergipark.org.tr
The purpose of this literature review was to systematize data from studies of the biological
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …