Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

A growing number of long nuclear‐retained non‐coding RNAs (ncRNAs) have recently been
described. However, few functions have been elucidated for these ncRNAs. Here, we have …

Communication between cells reaches its highest degree of specialization at chemical
synapses. Some synapses talk in a'whisper'; others' shout'. The'louder'the synapse, the more …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

The amyloid precursor protein (APP) is critical in the pathogenesis of Alzheimer's disease.
The question of its normal biological function in neurons, in which it is predominantly located …

▪ Abstract The actin cytoskeleton plays a major role in morphological development of
neurons and in structural changes of adult neurons. This article reviews the myriad functions …

The architecture of the actin cytoskeleton that concentrates at presynapses remains poorly
known, hindering our understanding of its roles in synaptic physiology. In this work, we …

Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …

Synapse formation and stabilization in the vertebrate central nervous system is a dynamic
process, requiring bi-directional communication between pre-and postsynaptic partners …