CCL4, a CC chemokine, previously known as macrophage inflammatory protein (MIP)-1β,
has diverse effects on various types of immune and nonimmune cells by the virtue of its …

Tumor microenvironment (TME) is characterized by mutual interactions of the tumor, stromal
and immune cells. Early and advanced colorectal tumors differ in structure and present …

Macrophages are among the most common cells in the colorectal cancer microenvironment,
but their prognostic significance is incompletely understood. Using multiplexed …

Tertiary lymphoid structures (TLS) are associated with favorable outcome in non-metastatic
colorectal carcinoma (nmCRC), but the dynamics of TLS maturation and its association with …

Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report
that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in …

A complex network of chemokines can influence cancer progression with the recruitment
and activation of hematopoietic cells, including macrophages to the supporting tumor stroma …

Anemia is common in colorectal cancer (CRC) but its relationships with tumor
characteristics, systemic inflammation, and survival have not been well characterized. In this …

Background Inflammation plays a pivotal role in the pathogenesis of cancer. Though
previous studies have reported a link between several inflammatory biomarkers and risk of …

Recent studies have reported of an association between high serum apolipoprotein A1
(APOA1) levels and favorable prognosis in several malignancies, while the significance of …

Introduction The host anti-tumour inflammatory response is a strong prognostic indicator,
and tumour infiltrating lymphocytes (TILs) are believed to have a complimentary role …