Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Metals such as mercury, arsenic, copper and silver have been used in various forms as
antimicrobials for thousands of years with until recently, little understanding of their mode of …

The emergence of new sequencing technologies has facilitated the use of bacterial whole
genome alignments for evolutionary studies and outbreak analyses. These datasets, of …

Recombination is an important evolutionary force in bacteria, but it remains challenging to
reconstruct the imports that occurred in the ancestry of a genomic sample. Here we present …

Background Next generation sequencing (NGS) technology has revolutionized genomic and
genetic research. The pace of change in this area is rapid with three major new sequencing …

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly
global challenge. In addition to the long-known healthcare-associated clones, novel strains …

Bacteria such as Staphylococcus aureus are successful as commensal organisms or
pathogens in part because they adapt rapidly to selective pressures imparted by the human …

The widespread use of antibiotics in association with high-density clinical care has driven
the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients …

Methods to reliably assess the accuracy of genome sequence data are lacking. Currently
completeness is only described qualitatively and mis-assemblies are overlooked. Here we …

The rapidly reducing cost of bacterial genome sequencing has lead to its routine use in
large-scale microbial analysis. Though mapping approaches can be used to find differences …