Breaking down the complex pathophysiology of eosinophilic esophagitis

B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …

The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders

SB Sindher, S Barshow, J Tirumalasetty, S Arasi… - Journal of Allergy and …, 2023 - Elsevier
Continuing insight into the molecular mechanisms of atopic disorders has enabled the
development of biologics to precisely target these diseases. Food allergy (FA) and …

[HTML][HTML] Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy

BL Wright, NQ Fernandez-Becker, N Kambham… - Frontiers in …, 2018 - frontiersin.org
Rationale: Oral immunotherapy (OIT) is an emerging treatment for food allergy. While
desensitization is achieved in most subjects, many experience gastrointestinal symptoms …

Risk factors and treatment outcomes for oral immunotherapy–induced gastrointestinal symptoms and eosinophilic responses (OITIGER)

MR Goldberg, L Nachshon, MB Levy, A Elizur… - The Journal of Allergy …, 2020 - Elsevier
Background We recently described that oral immunotherapy (OIT)-induced gastrointestinal
symptoms were associated with peripheral eosinophilic responses (termed OITIGER) …

The role of food allergy in eosinophilic esophagitis

JM Wilson, R Li, EC McGowan - Journal of asthma and allergy, 2020 - Taylor & Francis
Food allergy is often understood as an IgE-mediated hypersensitivity, characterized by
allergic symptoms which occur “immediately” after the ingestion of a relevant food allergen …

Eosinophil-associated gastrointestinal manifestations during OIT

MR Goldberg, N Epstein-Rigbi, A Elizur - Clinical Reviews in Allergy & …, 2023 - Springer
Gastrointestinal adverse events are common during oral immunotherapy (OIT) for food
allergy and range from immediate IgE-mediated reactions to non-anaphylactic clinical …

How to approach adult patients with asymptomatic esophageal eosinophilia

P Schreiner, L Biedermann, T Greuter… - Diseases of the …, 2021 - academic.oup.com
As the awareness among gastroenterologists regarding endoscopic features suggesting
eosinophilic esophagitis is increasing, individuals without symptoms of esophageal …

Eosinophilic esophagitis may persist after discontinuation of oral immunotherapy

L Hamant, C Freeman, S Garg, BL Wright… - Annals of Allergy …, 2021 - annallergy.org
180 (5): 388e395. 2. Bossley CJ, Fleming L, Ullmann N, et al. Assessment of corticosteroid
response in pediatric patients with severe asthma by using a multidomain approach. J …

Associations of Eosinophilic Gastrointestinal Disorders with Other Gastrointestinal and Allergic Diseases

S Oliva, EC McGowan - Immunology and Allergy Clinics, 2024 - immunology.theclinics.com
Eosinophilic gastrointestinal disorders (EGIDs) constitute a diverse group of conditions
marked by substantial eosinophilic inflammation affecting various segments of the digestive …

The Relationship Between Eosinophilic Esophagitis and Immunotherapy

BE Wilson, MA Sacta, BL Wright… - Immunology and …, 2024 - immunology.theclinics.com
Eosinophilic esophagitis (EoE) is a chronic disease associated with type 2 inflammation.
EoE usually requires long-term surveillance with esophagogastroduodenoscopy (EGD) and …