Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

Peptide therapeutics have played a notable role in medical practice since the advent of
insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and …

Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

For over 40 years, attempts to develop treatments that protect neurons and other brain cells
against the cellular and biochemical consequences of cerebral ischaemia in acute …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia …