Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies

K Giusto, H Wanczyk, T Jensen… - Disease Models & …, 2021 - journals.biologists.com
Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …

Planar cell polarity regulators in asymmetric organogenesis during development and disease

DL Shi - Journal of Genetics and Genomics, 2023 - Elsevier
The phenomenon of planar cell polarity is critically required for a myriad of morphogenetic
processes in metazoan and is accurately controlled by several conserved modules. Six …

Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance

J Ma, J Wang, C Ma, Q Cai, S Wu, W Hu, J Yang, J Xue… - Toxicology, 2023 - Elsevier
Silicosis is a chronic pulmonary disease characterized by diffuse fibrosis of lung caused by
the deposition of silica dust (SiO 2). The inhaled silica-induced oxidative stress, ROS …

Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis

T Trinh-Minh, CW Chen, CT Manh… - The Journal of …, 2024 - Am Soc Clin Investig
Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the
molecular regulation of the activation of latent TGF-β remains incompletely understood …

Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and …

S Esmail, W Danter - Stem cells translational medicine, 2021 - academic.oup.com
Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we
were not prepared. Several clinical trials using previously approved drugs and drug …

Extracellular vesicle surface signatures in IPF patients: A multiplex bead-based flow cytometry approach

M d'Alessandro, P Soccio, L Bergantini, P Cameli… - Cells, 2021 - mdpi.com
Background: Extracellular vesicles (EVs) are secreted by cells from their membrane within
circulation and body fluids. Knowledge of the involvement of EVs in pathogenesis of lung …

Alveologenesis: what governs secondary septa formation

AL Rippa, EV Alpeeva, AV Vasiliev… - International Journal of …, 2021 - mdpi.com
The simplification of alveoli leads to various lung pathologies such as bronchopulmonary
dysplasia and emphysema. Deep insight into the process of emergence of the secondary …

Moving bronchopulmonary dysplasia research from the bedside to the bench

M Gilfillan, V Bhandari - American Journal of Physiology …, 2022 - journals.physiology.org
Although advances in the respiratory management of extremely preterm infants have led to
improvements in survival, this progress has not yet extended to a reduction in the incidence …

Wnt5a promotes AT1 and represses AT2 lineage-specific gene expression in a cell-context-dependent manner

C Li, N Peinado, SM Smith, J Zhou, F Gao… - Stem Cells, 2022 - academic.oup.com
Lung maturation is not limited to proper structural development but also includes
differentiation and functionality of various highly specialized alveolar cell types. Alveolar …

[HTML][HTML] IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis

H He, J Snowball, F Sun, CL Na, JA Whitsett - JCI insight, 2021 - ncbi.nlm.nih.gov
Ventilation throughout life is dependent on the formation of pulmonary alveoli, which create
an extensive surface area in which the close apposition of respiratory epithelium and …