All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …

Abstract The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) affects numerous
behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major …

Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Serotonin, an important neuromodulator in the brain, is implicated in affective and cognitive
functions. However, its role even for basic cortical processes is controversial. For example …

Centrifugal serotonergic fibers innervating sensory brain areas are seen ubiquitously across
systems and species but their function remains unclear. Here we examined the functional …

Both generalized arousal and engagement in a specific task influence sensory neural
processing. To isolate effects of these state variables in the auditory system, we recorded …

While peripheral sensory neurons respond to natural stimuli with a broad range of
spatiotemporal frequencies, central neurons instead respond sparsely to specific features in …

In addition to ascending, descending, and lateral auditory projections, inputs extrinsic to the
auditory system also influence neural processing in the inferior colliculus (IC). These types …

Corticofugal projections to evolutionarily ancient, subcortical structures are ubiquitous
across mammalian sensory systems. These 'descending'pathways enable the neocortex to …

Internal state profoundly alters perception and behavior. For example, a starved fly may
approach and consume foods that it would otherwise find undesirable. A socially engaged …