There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

It has long been proposed that the cell cycle is regulated by physical forces at the cell–cell
and cell–extracellular matrix (ECM) interfaces,,,,,,,,,,–. However, the evolution of these forces …

In many vertebrate and invertebrate organisms, gametes develop within groups of
interconnected cells called germline cysts formed by several rounds of incomplete divisions …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Although rigidity and jamming transitions have been widely studied in physics and material
science, their importance in a number of biological processes, including embryo …

INTRODUCTION How biological properties scale with organ or body size is a question
fundamental to development and physiology; however, at the cellular level, the scaling …

What regulates the spatiotemporal distribution of cell elimination in tissues remains largely
unknown. This is particularly relevant for epithelia with high rates of cell elimination where …

The actomyosin cytoskeleton is responsible for most force-driven processes in cells and
tissues. How it assembles into the necessary structures at the right time and place is an …

Organ size is controlled by numerous factors including mechanical forces, which are
mediated in part by the Hippo pathway. In growing Drosophila epithelial tissues, cytoskeletal …