Zinc is an essential trace element that is crucial for growth, development, and the
maintenance of immune function. Its influence reaches all organs and cell types …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

All life forms have an absolute requirement for metals, as metals play critical roles in
fundamental processes, including osmotic regulation, catalysis, metabolism …

The nutritional essentiality of zinc for the growth of living organisms had been recognized
long before zinc biochemistry began with the discovery of zinc in carbonic anhydrase in …

The metal binding preferences of most metalloproteins do not match their metal
requirements. Thus, metallation of an estimated 30% of metalloenzymes is aided by metal …

Biology capitalizes on the specific chemistries of certain transition metal ions. In fact, life
depends on transition metal ions as essential trace elements. Biological redox processes …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Zinc, a redox-inactive metal, has been long viewed as a component of the antioxidant
network, and growing evidence points to its involvement in redox-regulated signaling. These …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …