▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …

Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …

Abstract IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid
homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play …

Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation,
expansion and acquisition of receptors that guide target cell specificity are not well defined …

Our understanding of human natural killer (NK) cell development lags far behind that of
human B‐or T‐cell development. Much of our recent knowledge of this incomplete picture …

▪ Abstract Natural killer (NK) cells play important roles in immunological processes, including
early defense against viral infections. This review provides an overview of the dynamic in …

Human natural killer (NK) cells originate from CD34 (+) hematopoietic progenitor cells, but
the discrete stages of NK cell differentiation in vivo have not been elucidated. We identify …

We know how B and T cells develop, what they'see'and the receptors they'see with'. By
contrast, and despite an unprecedented increase in the number of receptors and ligands …

In humans, T cells differentiate in thymus and B cells develop in bone marrow (BM), but the
natural killer (NK) precursor cell (s) and site (s) of NK development are unclear. The CD56 …

Natural killer (NK) cells play important roles in innate immunity by lysing tumor and virally
infected cells and by producing cytokines including interferon‐γ. While NK cell progenitors …