Changes in dopamine (DA) signaling have been implicated in a number of human
neurologic and psychiatric disorders. Similarly, defects in DA signaling in the fruit fly …

Neurodegenerative disorders are featured by a variety of pathological conditions that share
similar critical processes, such as oxidative stress, free radical activity, proteinaceous …

Abstract Alpha-synuclein (α-synuclein) aggregation and impairment of the Ubiquitin
proteasome system (UPS) are implicated in Parkinson's disease (PD) pathogenesis. While …

Macrophages are rapidly activated and polarized toward the M1 phenotype after spinal cord
injury (SCI), and inhibiting M1-like macrophages has emerged as a promising SCI treatment …

Objectives Ischemic cerebral infarction (ICI) is a fatal neurovascular disorder. A
bioinformatics approach based on single-cell and bulk RNA-seq analyses was applied to …

The total oxidative status (TOS)/total anti-oxidative status (TAS) ratio can provide information
on an individual's absolute oxidative stress index (OSI). We investigated the alterations in …

An association between excessive zinc (Zn) accumulation in brain and incidences of
Parkinson's disease (PD) has been shown in several epidemiological and experimental …

Abstract Wistar of the National Institute of Nutrition obese (WNIN/Ob) is a unique rat strain
isolated and established at NIN, Hyderabad, India, in 1996, from its existing stock of Wistar …

Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has
shown therapeutic potential. This work examines a nanoscale therapeutic modality for the …

Oxidative stress and inflammation are the key players in the toxic manifestation of sporadic
Parkinson's disease and zinc (Zn)-induced dopaminergic neurodegeneration. A synthetic …