Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Reducing the burden of infectious diseases that affect people in the developing world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …

Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

Introduction: Throughout history, natural products (NPs) have provided a rich source of
compounds that have wide applications in the fields of medicine, health sciences, pharmacy …

Secondary metabolites (SMs) found in medicinal plants are one of main sources of drugs,
cosmetics, and health products. With the increase in demand for these bioactive …

KRAS mutations drive a quarter of cancer mortality, and most are undruggable. Several
inhibitors of the MAPK pathway are FDA approved but poorly tolerated at the doses needed …

Malaria is an endemic disease that affected 229 million people and caused 409 thousand
deaths, in 2019. Disease control is based on early diagnosis and specific treatment with …

Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human
lives every year. Praziquantel (PZQ), the only drug recommended by the World Health …

Background: The antimalarial artesunate (ART), a semisynthetic derivative of artemisinin
from the Chinese herb a rtemisia annua has remarkable anticancer properties in vitro and in …

Malaria affects 200 million people worldwide. Today, the most successful treatments are
artemisinin-based combination therapies (ACT). Resistance has already been described for …