Adenoid cystic carcinoma (ACC) is a rare cancer with high potential for recurrence and
metastasis. Efficacy of current treatment options, particularly for advanced disease, is very …

The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate
protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of …

N6-methyladenine (m6A) RNA modification, as the most important modification of eukaryotic
messenger and long noncoding RNAs, 6 was first discovered in the purified poly (A) RNA …

Sepsis is a systemic inflammation caused by infection. The balance between M1–M2
macrophage polarization has an essential role in the pathogenesis of sepsis. However, the …

Colorectal cancer (CRC) is the second largest cause of cancer deaths in the United States.
A key barrier that prevents better outcomes for this type of cancer as well as other solid …

Background Tumor heterogeneity in breast cancer tumors is today widely recognized. Most
of the available knowledge in genetic variation however, relates to the primary tumor while …

Intracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is
a key signaling molecule that has diverse functions, from regulating metabolism and brain …

The role of calcium (Ca2+) and its dependent protease calpain in Aeromonas hydrophila-
induced head kidney macrophage (HKM) apoptosis has been reported. Here, we report the …

Aberrant cell survival plays a critical role in cancer progression and metastasis. We have
previously shown that ezrin, a cAMP-dependent protein kinase A–anchoring protein (AKAP) …

Pancreatic cancer (PC) is one of the most common malignant cancers, ranking the seventh
highest causes of cancer-related deaths globally. Recently, RNA N6-methyladenosine …