Catalyst-free thiazolidine formation chemistry enables the facile construction of peptide/protein–cell conjugates (PCCs) at physiological pH

X Liu, Y Wang, B Ye, X Bi - Chemical Science, 2023 - pubs.rsc.org
Although numerous genetic, chemical, and physical strategies have been developed to
remodel the cell surface landscape for basic research and the development of live cell …

Broaden the applications of peptidyl asparaginyl ligases

Y Xia - 2022 - dr.ntu.edu.sg
Peptidyl asparaginyl ligases (PALs) are highly active enzymes that catalyse peptide ligation
reactions through transpeptidation. To further increase the utility of PALs, I have successfully …

Expanding the scope of substrate specificity for peptide asparaginyl ligases

CK Lim - 2022 - dr.ntu.edu.sg
Asparaginyl endopeptidases (AEPs) are Asn/Asp (Asx)-specific proteases. Peptide
asparaginyl ligases (PALs) belong to AEPs that exhibit dominant ligase activity, making …