Spinal cord injury (SCI) often leads to an impairment of the respiratory system. The more
rostral the level of injury, the more likely the injury will affect ventilation. In fact, respiratory …

Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease,
representing the most common fatal pediatric pathology. Even though, classically and in a …

The control of voluntary skeletal muscle contraction relies on action potentials, which send
signals from the motor neuron through the neuromuscular junction (NMJ). Although …

The brain continues to develop during adolescence, and exposure to exogenous
substances such as nicotine can exert long-lasting adaptations during this vulnerable …

Background The development of the nervous system involves an initially exuberant
production of neurons that make an excessive number of synaptic contacts. The initial …

Nerve impulse activity produces both developmental and adult plastic changes in neural
networks. For development, however, its precise role and the mechanisms involved remain …

Besides initiating and propagating action potentials in established neuronal circuits, voltage-
dependent sodium channels sculpt and bolster the functional neuronal network from early in …

How circuits assemble starting from stem cells is a fundamental question in developmental
neurobiology. We test the hypothesis that, in neuronal stem cells, temporal transcription …

In many parts of the vertebrate nervous system, synaptic connections are remodeled during
early postnatal life. Neural activity plays an important role in regulating one such …

The protein kinase C family (PKC) regulates a variety of neural functions including
neurotransmitter release. The selective activation of a wide range of PKC isoforms in …