Members of the 14-3-3 family are homo-and the heterodimeric proteins mediating interaction
between diverse components of many biological activities. The role of these proteins has …

Abstract The 14-3-3 family of proteins mediates signal transduction by binding to
phosphoserine-containing proteins. Using phosphoserine-oriented peptide libraries to …

α-Synuclein has been implicated in the pathophysiology of many neurodegenerative
diseases, including Parkinson's disease (PD) and Alzheimer's disease. Mutations in α …

Abstract Members of the 14-3-3 family of proteins function as adapters/modulators that
recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular …

We have applied a proteomics approach to analyze signaling cascades in human platelets
stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP …

Several adaptor molecules bind to cytoplasmic tails of β-integrins and facilitate bidirectional
signaling, which is critical in thrombosis and hemostasis. Interfering with integrin-adaptor …

Recent studies have documented direct interaction between 14-3-3 proteins and key
molecules in signal transduction pathways like Ras, Cbl, and protein kinases. In T cells, the …

Dense granules, a type of platelet secretory organelle, are known to accumulate high
concentrations of small molecules such as calcium, adenine nucleotides, serotonin …

Background: Cold‐storage of platelets followed by rewarming induces changes in
Glycoprotein (GP) Ibα‐distribution indicative of receptor clustering and initiates thromboxane …

The effect of protein kinase C (PKC) on the release of neurotransmitters from a number
preparations, including sympathetic nerve endings, brain slices, synaptosomes, and …