Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Increasing amounts of data suggest that inflammatory responses have an important role in
the pathophysiology of depression. Depressed patients have been found to have higher …

This review discusses neurobiological and psychosocial factors associated with stress-
induced depression and compares these factors with those believed to characterize stress …

Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

Context A major limitation on the development of biomarkers and novel interventions for
schizophrenia is that its pathogenesis is unknown. Although elevated striatal dopamine …

Psychomotor retardation is a long established component of depression that can have
significant clinical and therapeutic implications for treatment. Due to its negative impact on …

Interferon-α is a potent inducer of the cytokine network and is notorious for causing
behavioral alterations. Studies on interferon-α-treated patients reveal at least two distinct …

A wealth of evidence has implicated inflammation in the development of depression. Yet, the
heterogeneous nature of depression has impeded efforts to understand, prevent, and treat …