Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential
J Wu, W Xu, Y Su, G Wang, J Ma - Acta pharmacologica Sinica, 2024 - nature.com
The pathological hallmarks of various neurodegenerative diseases including Parkinson's
disease and Alzheimer's disease prominently feature the accumulation of misfolded proteins …
disease and Alzheimer's disease prominently feature the accumulation of misfolded proteins …
[HTML][HTML] Advances and Challenges in Gene Therapy for Neurodegenerative Diseases: A Systematic Review
N García-González, J Gonçalves-Sánchez… - International Journal of …, 2024 - mdpi.com
This review explores recent advancements in gene therapy as a potential treatment for
neurodegenerative diseases, focusing on intervention mechanisms, administration routes …
neurodegenerative diseases, focusing on intervention mechanisms, administration routes …
[HTML][HTML] Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids
J Hidalgo-Álvarez, F Salas-Lucia, DV Cruz… - JCI insight, 2023 - ncbi.nlm.nih.gov
Thyroid hormone (TH) levels are low during development, and the deiodinases control TH
signaling through tissue-specific activation or inactivation of TH. Here, we studied human …
signaling through tissue-specific activation or inactivation of TH. Here, we studied human …
Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and amyotrophic lateral sclerosis
C Xiao, X Gu, Y Feng, J Shen - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Introduction Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly
understood pathophysiology. Recent studies have highlighted systemic inflammation …
understood pathophysiology. Recent studies have highlighted systemic inflammation …
[HTML][HTML] Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin
(PGRN), are associated with several neurodegenerative diseases, including frontotemporal …
(PGRN), are associated with several neurodegenerative diseases, including frontotemporal …
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
ME Bekier III, E Pinarbasi, JJ Mesojedec, L Ghaffari… - bioRxiv, 2025 - biorxiv.org
Cytoplasmic TDP43 mislocalization and aggregation are pathological hallmarks of
amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 …
amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 …
An Overview of Protein Kinase Inhibitors
SK De - Drug Design and Discovery: Inhibitors of Mitogen …, 2024 - Springer
Protein kinases become one of the most successful drug targets for the treatment of various
diseases. Protein kinase catalyzes the transfer of the γ-phosphoryl group of the ATP to …
diseases. Protein kinase catalyzes the transfer of the γ-phosphoryl group of the ATP to …
Terapia génica en enfermedades neurodegenerativas
N García González - 2024 - gredos.usal.es
[ES] Analizamos el uso de las terapias génicas como medio para desarrollar nuevos
tratamientos en las enfermedades neurodegenerativas, evaluando los niveles de …
tratamientos en las enfermedades neurodegenerativas, evaluando los niveles de …