Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

The type I interferon (IFN) system mediates a wide variety of antiviral effects and represents
an important first barrier to virus infection. Consequently, viruses have developed an …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …

Abstract Edited by Jiarui Wu Cytosolic nucleic acid sensors are critical for sensing nucleic
acids and initiating innate immunity during microbial infections and/or cell death. Over the …

Varicella zoster virus (VZV) causes chickenpox in humans and, subsequently, establishes
latency in the sensory ganglia from where it reactivates to cause herpes zoster. Infection of …

Early detection of infectious nucleic acids released from invading pathogens by the innate
immune system is critical for immune defense. Detection of these nucleic acids by host …

Viruses commonly antagonize the antiviral type I interferon response by targeting signal
transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon …

In mammalian cells, early defenses against infection by pathogens are mounted through a
complex network of signaling pathways shepherded by immune-modulatory pattern …

Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the herpesvirus family, has
evolved to establish a long-term, latent infection of cells such that while they carry the viral …

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman …