Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human
coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory …

A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the
envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif …

A SARS-CoV lacking the full-length E gene (SARS-CoV-∆ E) was attenuated and an
effective vaccine. Here, we show that this mutant virus regained fitness after serial passages …

The allosteric mechanism plays a key role in cellular functions of several PDZ domain
proteins (PDZs) and is directly linked to pharmaceutical applications; however, it is a …

β-lactamases are produced by many modern bacteria as a mechanism of resistance toward
β-lactam antibiotics, the most common antibiotics in use. β-lactamases, however, are ancient …

Linking cell signaling events to the fundamental physicochemical basis of the
conformational behavior of single molecules and ultimately to cellular function is a key …

The PDZ domain is a protein–protein interacting module that plays an important role in the
organization of signaling complexes. The recognition of short intrinsically disordered C …

Controlling the activity of proteins with azobenzene photoswitches is a potent tool for
manipulating their biological function. With the help of light, it is possible to change binding …

Using the perturbation-response scanning (PRS) technique, we study a set of 25 proteins
that display a variety of conformational motions upon ligand binding (eg, shear, hinge …