The cellular architecture of the antimicrobial response network in human leprosy granulomas

F Ma, TK Hughes, RMB Teles, PR Andrade… - Nature …, 2021 - nature.com
Granulomas are complex cellular structures composed predominantly of macrophages and
lymphocytes that function to contain and kill invading pathogens. Here, we investigated the …

An update on leprosy immunopathogenesis: systematic review

MJA Silva, CS Silva, TP Brasil, AK Alves… - Frontiers in …, 2024 - frontiersin.org
Introduction Leprosy is a chronic infectious condition and the main cause of neuropathy that
occurs brought on by M. leprae. It is known that the biological characteristics of the human …

Blood RNA signature RISK4LEP predicts leprosy years before clinical onset

M Tió-Coma, SM Kiełbasa, SJF van den Eeden… - …, 2021 - thelancet.com
Background Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is often
late-or misdiagnosed leading to irreversible disabilities. Blood transcriptomic biomarkers …

Xenophagy as a Strategy for Mycobacterium leprae Elimination during Type 1 or Type 2 Leprosy Reactions: A Systematic Review

DDN Cerqueira, ALS Pereira, AEC da Costa… - Pathogens, 2023 - mdpi.com
Background: Mycobacterium leprae is an intracellular bacillus that causes leprosy, a
neglected disease that affects macrophages and Schwann cells. Leprosy reactions are …

Gene Expression Profile of Mycobacterium leprae Contribution in the Pathology of Leprosy Neuropathy

BJ Souza, MA Mendes, GM Sperandio da Silva… - Frontiers in …, 2022 - frontiersin.org
Peripheral neuropathy is the main cause of physical disability in leprosy patients.
Importantly, the extension and pattern of peripheral damage has been linked to how the host …

Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model

V Kreis, C Toffano-Nioche, C Denève-Larrazet… - …, 2024 - journals.asm.org
Clostridioides difficile is the leading cause of healthcare-associated diarrhea in
industrialized countries. Many questions remain to be answered about the mechanisms …

Single cell and spatial transcriptomics defines the cellular architecture of the antimicrobial response network in human leprosy granulomas

F Ma, TK Hughes, RMB Teles, PR Andrade… - BioRxiv, 2020 - biorxiv.org
Granulomas are complex cellular structures comprised predominantly of macrophages and
lymphocytes that function to contain and kill invading pathogens. Here, we investigated …

Different cell death mechanisms are involved in leprosy pathogenesis

JR de Sousa, LFM Falcão, GL Virgolino, MFS Cruz… - Microbial …, 2022 - Elsevier
Leprosy is a chronic granulomatous disease that remains a serious public health problem in
developing countries. According to the Madrid classification, leprosy presents in four clinical …

Assessment of key regulatory genes and identification of possible drug targets for Leprosy (Hansen's disease) using network-based approach

M Khan, S Khan, M Lohani, MM Ahmed… - Biotechnology and …, 2023 - Taylor & Francis
Leprosy is a major health concern and continues to be a source of fear and stigma among
people worldwide. Despite remarkable achievements in the treatment, understanding of …

[HTML][HTML] Human macrophage polarization in the response to Mycobacterium leprae genomic DNA

A Marin, K Van Huss, J Corbett, S Kim, J Mohl… - Current Research in …, 2021 - Elsevier
Infection with Mycobacterium leprae, the causative organism of leprosy, is still endemic in
numerous parts of the world including the southwestern United States. The broad variation …