The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …

Indirect neurogenesis, during which neural stem cells generate neurons through
intermediate progenitors, drives the evolution of lissencephalic brains to gyrencephalic …

Tumors constantly interact with their microenvironment. Here, we present data on a Notch-
induced neural stem cell (NSC) tumor in Drosophila, which can be immortalized by serial …

Nervous systems of bilaterian animals generally consist of two cell types: neurons and glial
cells. Despite accumulating data about the many important functions glial cells serve in …

Dedifferentiation is the reversion of mature cells to a stem cell‐like fate, whereby gene
expression programs are altered and genes associated with multipotency are (re) …

Temporal patterning is an important mechanism for generating a great diversity of neuron
subtypes from a seemingly homogenous progenitor pool in both vertebrates and …

The execution of a Notch signal at the plasma membrane relies on the mechanical force
exerted onto Notch by its ligand. It has been appreciated that the DSL ligands need to …

Abstract Chordin-like 1 (CHRDL1) is a secreted protein that serves as an endogenous
antagonist of bone morphogenetic proteins (BMPs). In the developing retina, Bmp4 has …

This protocol describes the allotransplantation of tumors in Drosophila melanogaster using
an auto-nanoliter injection apparatus. With the use of an autoinjector apparatus, trained …

Background: Neural stem cells (NSC) in divide asymmetrically to generate one cell that
retains stem cell identity and another that is routed to differentiation. Prolonged mitotic …