N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …

Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Synapse development requires differentiation of presynaptic neurotransmitter release sites
and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In …

As the major components of the postsynaptic density of excitatory neuronal synapses, PDZ-
domain-containing scaffold proteins regulate the clustering of surface glutamate receptors …

The ADP ribosylation factors (Arfs) are a family of small, ubiquitously expressed and
evolutionarily conserved guanosine triphosphatases that are key regulators of vesicular …

The nerve growth factor family of growth factors, collectively known as neurotrophins, are
evolutionarily ancient regulators with an enormous range of biological functions. Reflecting …

The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family
of growth factor receptors required for neuronal survival. They have since been shown to …

Neurotrophin receptor tyrosine kinases (Trks) have well-defined trophic roles in nervous
system development through kinase activation by neurotrophins. Yet Trks have typical cell …

Cell migration is a fundamental biological process involved in normal physiology. Altered
motile phenotypes are however often associated with the development and progression of …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …