In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …

Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory
mechanism in eukaryotic gene expression that controls the proper function of proteins. It is …

The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive
form of early-onset Alzheimer's disease (AD) is unknown, but fibroblasts from mutation …

Alterations in transcription, RNA editing, translation, protein processing, and clearance are a
consistent feature of Alzheimer's disease (AD) brain. To extend our initial study (Alzheimer …

Few diseases are characterized by high homocysteine (HCY) and low folate and vitamin
B12 blood levels. Alzheimer disease (AD) is among these. It has already been shown that …

Two closely related genes, the presenilins (PS), located at chromosomes 14q24. 3 and
1q42. 1, have been identified for autosomal dominant Alzheimer disease (AD) with onset …

The presenilin 1 and presenilin 2 genes have been identified as pathogenic loci involved in
the majority of early onset, autosomal dominant Alzheimer's disease. A series of …

The processing of amyloid precursor protein (APP) generates amyloid-β (Aβ) peptides 1–40
and 1–42. The latter is neurotoxic and its accumulation results in amyloid fibril formation and …

Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

It is now 10 years since the first report of mutations in the presenilin genes that were
deterministic for familial autosomal dominant Alzheimer's disease. The most common of …