BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …

Infertility affects approximately 15% of reproductive-aged couples worldwide, of which up to
30% of the cases are caused by male factors alone. The origin of male infertility is mostly …

Objective To investigate the extent to which assisted oocyte activation (AOA) improves
clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). Design …

This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …

Objective To investigate the applicability of phospholipase C zeta (PLCζ) analysis in
assisting the clinical decision-making process when considering artificial oocyte activation …

Purpose Globozoospermia is a genetic syndrome characterized by the presence of round-
headed spermatozoa and infertility due to the inability of these spermatozoa to fertilize the …

Since the advent of ART, technology has continuously evolved to improve embryology and
pregnancy outcomes. However, not all technologies that are integrated into practice have …

Calcium (Ca2+) is a second messenger for many signal pathways, and changes in
intracellular Ca2+ concentration ([Ca2+] i) are an important signaling mechanism in the …

Background Artificial oocyte activation (AOA) is used to improve fertilization rate following
fertilization failure after intracytoplasmic sperm injection (ICSI). Several studies have also …