Stiffness sensing by cells

PA Janmey, DA Fletcher… - Physiological …, 2020 - journals.physiology.org
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging

MA Cole, T Quan, JJ Voorhees, GJ Fisher - Journal of cell communication …, 2018 - Springer
The dermal extracellular matrix (ECM) comprises the bulk of skin and confers strength and
resiliency. In young skin, fibroblasts produce and adhere to the dermal ECM, which is …

A comparison of methods to assess cell mechanical properties

PH Wu, DRB Aroush, A Asnacios, WC Chen… - Nature …, 2018 - nature.com
The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …

Tensegrity, cellular biophysics, and the mechanics of living systems

DE Ingber, N Wang, D Stamenović - Reports on Progress in …, 2014 - iopscience.iop.org
The recent convergence between physics and biology has led many physicists to enter the
fields of cell and developmental biology. One of the most exciting areas of interest has been …

Geometric control of cell life and death

CS Chen, M Mrksich, S Huang, GM Whitesides… - Science, 1997 - science.org
Human and bovine capillary endothelial cells were switched from growth to apoptosis by
using micropatterned substrates that contained extracellular matrix-coated adhesive islands …

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

AJ Maniotis, CS Chen… - Proceedings of the …, 1997 - National Acad Sciences
We report here that living cells and nuclei are hard-wired such that a mechanical tug on cell
surface receptors can immediately change the organization of molecular assemblies in the …

Tensegrity: the architectural basis of cellular mechanotransduction

DE Ingber - Annual review of physiology, 1997 - annualreviews.org
▪ Abstract Physical forces of gravity, hemodynamic stresses, and movement play a critical
role in tissue development. Yet, little is known about how cells convert these mechanical …

Tensegrity I. Cell structure and hierarchical systems biology

DE Ingber - Journal of cell science, 2003 - journals.biologists.com
In 1993, a Commentary in this journal described how a simple mechanical model of cell
structure based on tensegrity architecture can help to explain how cell shape, movement …

[HTML][HTML] Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

MR Zanotelli, A Rahman-Zaman… - Nature …, 2019 - nature.com
Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a
spatially complex microenvironment that presents directional choices to migrating cells …

Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness

S Hameroff, R Penrose - Mathematics and computers in simulation, 1996 - Elsevier
Features of consciousness difficult to understand in terms of conventional neuroscience
have evoked application of quantum theory, which describes the fundamental behavior of …