Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

The therapeutic efficacy of whole tumor cell vaccines (TCVs) is modest, which has delayed
their translation into personalized immunotherapies in the clinic. Here, we develop a TCV …

The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that
enhances innate immune responses. CD14 was first identified as a marker of monocytes to …

Extracellular vesicles (EVs) released by neural cells play an essential role in brain
homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a
population of immature myeloid cells with the ability to suppress T cell activation. They …