The acidity of intracellular compartments and the extracellular environment is crucial to
various cellular processes, including membrane trafficking, protein degradation, bone …

Vacuolar-type H+-ATPase (V-ATPase)-driven proton pumping and organellar acidification is
essential for vesicular trafficking along both the exocytotic and endocytotic pathways of …

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome
acidification and maturation processes after engulfment by macrophages. Here, we show …

The vacuolar (H+)-ATPases are ATP-dependent proton pumps that acidify intracellular
compartments and, in some cases, transport protons across the plasma membrane of …

Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent
transport of protons. In addition to their role in acidifying the lumen of various intracellular …

The eukaryotic V-type adenosine triphosphatase (V-ATPase) is a multi-subunit membrane
protein complex that is evolutionarily related to F-type adenosine triphosphate (ATP) …

Abstract Vacuolar-type ATPase (V-ATPase), initially identified in yeast and plant vacuoles,
pumps protons into the lumen of organelles coupled with ATP hydrolysis. The mammalian …

The vacuolar-type H+-ATPases (V-ATPase) hydrolyze ATP to pump protons across the
plasma or intracellular membrane, secreting acids to the lumen or acidifying intracellular …

The lumen of endosomal organelles becomes increasingly acidic when going from the cell
surface to lysosomes. Luminal pH thereby regulates important processes such as the …

Eukaryotic cells have evolved a family of ATP-dependent proton pumps known as the
vacuolar (H+)-ATPases (or V-ATPases) to regulate the pH of intracellular compartments, the …