Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's
disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor …

Sarcopenia is characterized by reduced skeletal muscle mass and strength in older
individuals. It is one of the leading cause of physical limitation in older adults, and …

Skeletal muscle macrophages participate in repair and regeneration following injury.
However, their role in physiological adaptations to exercise is unexplored. We determined …

Macrophages are an essential component of the immune response to ischaemic injury and
play an important role in promoting inflammation and its resolution, which is necessary for …

Background: Metabolic pathways perturbations lead to skeletal muscular atrophy in the
cachexia and sarcopenia due to increased catabolism. Pro-inflammatory cytokines induce …

Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation
of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein …

Satellite cells are a stem cell population within adult muscle and are responsible for
myofiber regeneration upon injury. Satellite cell dysfunction has been shown to underlie the …

Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly
compromised with advancing age. In this study, we demonstrate that increased NF-κB …

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) through binding to its
receptor fibroblast growth factor inducible 14 (Fn14) has been shown to regulate many …

Mammalian skeletal muscle maintains a robust regenerative capacity throughout life, largely
due to the presence of a stem cell population known as “satellite cells” in the muscle milieu …