Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
[HTML][HTML] CTCF and cohesin: linking gene regulatory elements with their targets
M Merkenschlager, DT Odom - Cell, 2013 - cell.com
Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …
regulatory elements based on chromatin features and transcriptional regulator binding and …
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Abstract Background Type II DNA topoisomerases (TOP2) regulate DNA topology by
generating transient double stranded breaks during replication and transcription …
generating transient double stranded breaks during replication and transcription …
[HTML][HTML] Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
A Kazanets, T Shorstova, K Hilmi, M Marques… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …
there are a number of universal aberrations common to all cancers, one of these being the …
Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes
SJ Goodfellow, JCBM Zomerdijk - Epigenetics: development and disease, 2012 - Springer
Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …
Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans
Ribosomes are essential intracellular machines composed of proteins and RNA molecules.
The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and …
The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and …
CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells
The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation
and transcription through selective binding to thousands of genomic sites. Here, we …
and transcription through selective binding to thousands of genomic sites. Here, we …
Integrative genomic analysis of human ribosomal DNA
GE Zentner, A Saiakhova, P Manaenkov… - Nucleic acids …, 2011 - academic.oup.com
The transcription of ribosomal RNA (rRNA) is critical to life. Despite its importance, ribosomal
DNA (rDNA) is not included in current genome assemblies and, consequently, genomic …
DNA (rDNA) is not included in current genome assemblies and, consequently, genomic …
Ribosomal DNA and the nucleolus in the context of genome organization
TA Potapova, JL Gerton - Chromosome Research, 2019 - Springer
The nucleolus constitutes a prominent nuclear compartment, a membraneless organelle that
was first documented in the 1830s. The fact that specific chromosomal regions were present …
was first documented in the 1830s. The fact that specific chromosomal regions were present …