Transgelin 2 guards T cell lipid metabolism and antitumour function

SM Hwang, D Awasthi, J Jeong, TA Sandoval… - Nature, 2024 - nature.com
Mounting effective immunity against pathogens and tumours relies on the successful
metabolic programming of T cells by extracellular fatty acids,–. Fatty-acid-binding protein 5 …

[HTML][HTML] Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy

L Yang, X Wang, S Wang, J Shen, Y Li, S Wan… - … et Biophysica Acta (BBA …, 2025 - Elsevier
As immunosuppressive cells, Regulatory T cells (Tregs) exert their influence on tumor
immune escape within the tumor microenvironment (TME) by effectively suppressing the …

[HTML][HTML] Utilization of Cannabidiol in Post-Organ-Transplant Care

S Koyama, J Etkins, J Jun, M Miller… - International …, 2025 - pmc.ncbi.nlm.nih.gov
Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis
sativa, widely recognized for its therapeutic potential. While cannabis has been utilized for …

GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma

R Sun, Y Liu, Y Sun, M Zhou, Y Wang, B Shi… - Acta Pharmacologica …, 2024 - nature.com
Chimeric antigen receptor-expressing T (CAR-T) cells induce robust antitumor responses in
patients with hematologic malignancies. However, CAR-T cells exhibit only limited efficacy …

[HTML][HTML] A Novel Prognostic Signature of comprising Nine NK Cell signatures Based on Both Bulk RNA Sequencing and Single-Cell RNA Sequencing for …

Q Yu, X Shi, H Wang, S Zhang, S Hu, T Cai - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Background: Hepatocellular carcinoma (HCC) has limited prognostic prediction due to its
heterogeneity. Understanding the role of natural killer (NK) cells in HCC is vital for prognosis …

[HTML][HTML] Lipids in the tumor microenvironment: immune modulation and metastasis

G Pascual, SA Benitah - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Tumor cells can undergo metabolic adaptations that support their growth, invasion, and
metastasis, such as reprogramming lipid metabolism to meet their energy demands and to …

[HTML][HTML] RNA splicing regulator EIF3D regulates the tumor microenvironment through immunogene-related alternative splicing in head and neck squamous cell …

D Lu, M Mihoayi, Y Ablikim, A Arikin - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Study finds that eukaryotic translation initiation factor 3 subunit D (EIF3D) may play an
important role in aberrant alternative splicing (AS) events in tumors. AS possesses a pivotal …

[HTML][HTML] Multi-omic analysis revealed the immunological patterns and diagnostic value of exhausted T cell-derived PTTG1 in patients with psoriasis

X Zhou, J Ning, R Cai, J Liu, H Yang, Q Liu, J Lv… - Biochemical and …, 2024 - Elsevier
Background Psoriasis, characterized by chronic inflammation, is a persistent skin condition
that is notoriously challenging to manage and prone to relapse. Despite significant …

Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats

S Yi, T Mai, Y Fang, Q Tian… - Journal of Biochemical and …, 2025 - Wiley Online Library
With the gradual emergence of xylazine as a street drug, incidents of xylazine poisoning are
now occurring worldwide. However, it remains unknown whether long‐term exposure to …

Glycolysis-Metabolism-Related Prognostic Signature for Ewing Sarcoma Patients

F Jia, L Liu, Q Weng, H Zhang, X Zhao - Molecular Biotechnology, 2024 - Springer
Ewing sarcoma (EwS) is a malignant sarcoma which occurs in bone and soft tissues
commonly happening in children with poor survival rates. Changes in cell metabolism, such …