Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Commensal organisms that constitute the skin microbiota play a pivotal role in the
orchestration of cutaneous homeostasis and immune competence. This balance can be …

Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in
cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal …

Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs)
and macrophages. A lack of consensus regarding how to define these cell types has …

The skin harbors a variety of resident leukocyte subsets that must be tightly regulated to
maintain immune homeostasis. Hair follicles are unique structures in the skin that contribute …

Our assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis
have undergone considerable changes. Once thought to be prototypic representatives of the …

Atopic dermatitis (AD) is a common skin condition, characterized by a complex,
heterogeneous pathogenesis, including skin barrier dysfunctions, allergy/immunology, and …

The skin is a highly complex organ interspersed with a variety of smaller organ-like
structures and a plethora of cell types that together perform essential functions such as …

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies,
cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin …

In the last few decades, our understanding of Langerhans cells (LCs) has drastically
changed based on novel findings regarding the developmental origin and biological …